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Side effects were dose-dependent, which is why the dose is titrated upward gradually rather than starting at the full dose

In this context, although while studies conducted in meta-analyses suggest that a consistent circadian rhythm is not observed, possibly due to small sample sizes, a recent study reported that sphingolipids and phospholipids exhibit higher concentrations in the evenings, with diacylglycerols and triacylglycerols showing more pronounced circadian variation compared to phospholipids and sphingolipids [3, 33]

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[DOI] [PubMed] [Google Scholar] 30.Khaliq A., Foreman D., Ahmed A., Weich H., Gregor Z., McLeod D., Boulton M